Topoisomerase II checkpoints: Universal mechanisms that regulate mitosis
- Duncan J. Clarkeb(Author),
- Amit C. Vasb(Author),
- Catherine A. Andrewsb(Author),
- ,
- Juan F. Giménez-Abiánb, c(Author)
- aDepartment of Genetics; Cell Biology and Development,
- bUniversity of Minnesota Medical School,
- cCSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
Research Output: Contribution to journal Short survey Peer-review
Open access
Abstract
Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.
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