The complexity of life and death decisions in mitosis

Laura A. Diaz-Martinez(corresponding author)
,
Hongtao Yu

*Corresponding author for this work

UT-Southwestern Medical Center
,
Department of Pharmacology

Research Output:

Contribution to journal

Article

Peer-review

Open access

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Abstract

The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.

Access to documents

10.4161/23723548.2014.969658

License:CC BY-NC

Sustainable Development Goals

SDG 3 Good Health and Well

Bibliographic Information

Output type

Research Output:

Contribution to journal

Article

Peer-review

Original language

English

Article number

e969658

Journal (Volume, Issue Number)

Molecular and Cellular Oncology (Volume 2, Issue 2)

Publication milestones

Published - 03/04/2015

Publication status

Published - 03/04/2015

Publication IDs

Scopus: 85051800442