The complexity of life and death decisions in mitosis
- ,
- Hongtao Yu
- UT-Southwestern Medical Center,
- Department of Pharmacology
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Abstract
The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.
Sustainable Development Goals
SDG 3 Good Health and Well
Bibliographic Information
Output type
Research Output:
Contribution to journal
Article
Peer-reviewOriginal language
EnglishArticle number
e969658Journal (Volume, Issue Number)
Molecular and Cellular Oncology (Volume 2, Issue 2)Publication milestones
- Published - 03/04/2015
Publication status
Published - 03/04/2015
Publication IDs
- Scopus: 85051800442