The complexity of life and death decisions in mitosis
- ,
- Hongtao Yua(Author)
- aUT-Southwestern Medical Center,
- bDepartment of Pharmacology
Research Output: Contribution to journal Article Peer-review
Open access
Abstract
The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.
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Sustainable Development Goals
SDG 3 Good Health and Well