Stabilized porous phospholipid nanoshells
- Zhiliang Chenga(Author),
- ,
- Craig A. Aspinwalla(Author)
- aDepartment of Chemistry and Biochemistry
Research Output: Contribution to journal Article Peer-review
Abstract
Chemically stabilized, porous phospholipid nanoshells (PPNs) were prepared via copolymerization of reactive monomers with unilamellar bis-Sorbyl phosphatidylcholine vesicles. The resulting PPN vesicular assemblies possess a highly porous membrane structure that allows passage of small molecules, which can react with encapsulated proteins and reporters. The unique combination of membrane stability and porosity will prove useful for preparing nanometersized sensor, container, and reactor platforms stable in harsh chemical and biological environments.