Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge
- ,
- Peyton V. Warpa(Author),
- Rachael Shklyarova(Author),
- James D. Thomasa(Author),
- Maurice S. Swansona(Author),
- Jessica L. Henty-Ridillad(Author)
- aUniversity of Florida College of Medicine,
- bDepartment of Anatomy and Cell Biology,
- cCenter for Translational Research in Neurodegenerative Disease,
- dSUNY Upstate Medical University
Research Output: Contribution to journal Article Peer-review
Open access
Abstract
How do different actin structures assemble from a common monomer pool? Skruber et al. show that the monomer-binding protein PFN1 is required for Arp2/3 and Mena/VASP network assembly at the leading edge. Altering PFN1 concentration changes how these networks compete and collaborate, driving the formation of different leading-edge actin structures.