Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge
- ,
- Peyton V. Warp,
- Rachael Shklyarov,
- James D. Thomas,
- Maurice S. Swanson,
- Jessica L. Henty-Ridilla
- University of Florida College of Medicine,
- Department of Anatomy and Cell Biology,
- Center for Translational Research in Neurodegenerative Disease,
- SUNY Upstate Medical University
Research Output: Contribution to journal Article Peer-review
Open access
Abstract
How do different actin structures assemble from a common monomer pool? Skruber et al. show that the monomer-binding protein PFN1 is required for Arp2/3 and Mena/VASP network assembly at the leading edge. Altering PFN1 concentration changes how these networks compete and collaborate, driving the formation of different leading-edge actin structures.
Bibliographic Information
Output type
Research Output: Contribution to journal Article Peer-review
Original language
EnglishPages from-to (Number of pages)
Pages 2651-2664.e5Journal (Volume, Issue Number)
Current Biology (Volume 30, Issue 14)Publication milestones
- Published - 20/07/2020
Publication status
Published - 20/07/2020
ISSN
0960-9822Publication IDs
- Scopus: 85086401601
- PubMed: 32470361