Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography
- ,
- Sung Hoon Leea, b(Author),
- Matthew Guessa(Author),
- Woon Hong Yeoa, d(Author)
- aGeorgia Institute of Technology,
- bSchool of Electrical and Computer Engineering,
- cIEN Center for Human-Centric Interfaces and Engineering at the Institute for Electronics and Nanotechnology,
- dWallace H. Coulter Department of Biomedical Engineering
Open access
Abstract
Vasoconstriction is a crucial physiological process that serves as the body's primary blood pressure regulation mechanism and a key marker of numerous harmful health conditions. The ability to detect vasoconstriction in real time would be crucial for detecting blood pressure, identifying sympathetic arousals, characterizing patient wellbeing, detecting sickle cell anemia attacks early, and identifying complications caused by hypertension medications. However, vasoconstriction manifests weakly in traditional photoplethysmogram (PPG) measurement locations, like the finger, toe, and ear. Here, we report a wireless, fully integrated, soft sternal patch to capture PPG signals from the sternum, an anatomical region that exhibits a robust vasoconstrictive response. With healthy controls, the device is highly capable of detecting vasoconstriction induced endogenously and exogenously. Furthermore, in overnight trials with patients with sleep apnea, the device shows a high agreement (r2 = 0.74) in vasoconstriction detection with a commercial system, demonstrating its potential use in portable, continuous, long-term vasoconstriction monitoring.