Direct synthesis of trimethyl(2-phenoxyethyl)silanes from aromatic fluorides

Scott A. Grecian
,
Sabine Hadida
,
Stephen D. Warren(corresponding author)

*Corresponding author for this work

DuPont
,
University of Kansas
,
Vertex Pharmaceuticals Inc.
,
Chemistry & Biochemistry

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Abstract

A direct synthesis of trimethyl(2-phenoxyethyl)silanes from the corresponding aromatic fluorides and 2-(trimethylsilyl)ethanol was developed. A variety of substituents were tolerated and a substitution reaction using 1-bromo-3-chloro-5-fluorobenzene was demonstrated.

Access to documents

10.1016/j.tetlet.2005.04.111

Bibliographic Information

Output type

Research Output:

Contribution to journal

Article

Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 4683-4685 (3 pages)

Journal (Volume, Issue Number)

Tetrahedron Letters (Volume 46, Issue 27)

Publication milestones

Published - 04/07/2005

Publication status

Published - 04/07/2005

ISSN

0040-4039

Publication IDs

Scopus: 20344403036